In line with the stress-related model of depersonalization, those neurotransmitter systems of relevance to depersonalization are known to play important inhibitory roles in the regulation of the stress response. Similarly, the use of clonazepam, particularly in conjunction with SSRI antidepressants, appears to be beneficial in patients with high levels of background anxiety. However, open-label trials suggest that its use as an add-on treatment with selective serotonin reuptake inhibitors (SSRIs) is beneficial in a substantial number of patients. However, conclusive evidence supports the fact that a person who suffers from this disorder loses or modifies the general sense of their own reality. Most dissociative disorder findings are a subject of controversy. In spite of initial expectations, the use of lamotrigine as a sole medication has not been found useful. Depersonalization Disorder (DPD) or dissociative disorder affects the way a person experiences his or her self amid reality. For example, a number of studies suggest that opioid receptor antagonists such as naltrexone and naloxone are useful in at least a subgroup of patients. Fortunately, a few promising lines of pharmacological treatment have emerged in recent years, although more rigorous studies are needed. Depersonalization remains a condition for which no definitive treatment exists, and for which conventional medications, such as antidepressants or antipsychotics, have been found to be of little value. In DPD, such a response would become chronic and dysfunctional.

Such a mechanism would ensure the preservation of adaptive behavior, during situations normally associated with overwhelming and potentially disorganizing anxiety. Such findings are in line with a model which suggests that the condition is generated by an anxiety-triggered, ’hard-wired’ inhibitory response to threat. Several neurobiological studies in the last decade have shown that patients have suppressed limbic activation to emotional stimuli. Many people with a dissociative disorder make a full. Depersonalization-derealization disorder (DPDR, DPD) is a mental disorder in which the person has persistent or recurrent feelings of depersonalization or derealization.Depersonalization is described as feeling disconnected or detached from ones self. People from all age groups and racial, ethnic and socioeconomic backgrounds can experience a dissociative disorder. Some dissociative disorders are very shortlived, perhaps following a traumatic life event, and resolve on their own over a matter of weeks or months. Dissociative disorders are characterized by an involuntary escape from reality characterized by a disconnection between thoughts, identity, consciousness and memory. Depersonalization disorder (DPD) is a chronic and distressing condition with a prevalence in the general population between 0.8 and 2%. Dissociative disorders are a range of conditions that can cause physical and psychological problems.

Depersonalization disorder treatments